The central importance of solvent interactions in stabilization of specific protein structure has long been recognized decades ago tanford and kirkwood . Protein protein interactions ppis are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical . The stability of proteins is affected by a variety of solvent additives sugars certain amino acids and salts and polyhydric alcohols stabilize proteins . Solvation effects upon the thermodynamic substrate activity correlation with the kinetics of enzyme catalyzed reactions ii more complex interactions of alpha . Protein solvent preferential interactions protein hydration and the modulation of biochemical reactions by solvent components serge n timasheff
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